Projects
| Shorttitle | Scientist responsible for the study | Topic |
|---|---|---|
Allosteric interactions on HERG channels
| Bernd-Joachim Zünkler | Electrophysiological and fluorescence microscopy studies of allosteric interactions on HERG channels |
| Antiepileptic action of bromide | Marco Weiergräber (BfArM) Rüdiger Köhling (Rostock) | Antiepileptic mechanisms of bromide: in vitro and in vivo analysis using a chronic epilepsy modell |
PCR of medicinal plants
| Werner Knöss | Development and validation of molecular biological methods for identification of medicinal plants in herbal substances, herbal preparations and finished products |
| Biomarker for mechanisms of genotoxicity | Roland Frötschl | Identification of biomarker to predict the genotoxic mechanism of action |
Interaction between immediate packaging and drug formulation
| Cornelia Lipperheide | Influence of plastic containers and inner tube coatings on pharmaceutical quality |
| CD66b | Norbert Schnitzler Thomas Grüger Thomas Schmidt | Function and regulation of the granulocyte marker CD66b and its role in the phagocytosis and killing of pathogens |
| Data analysis herbal substances | Werner Knöss Gabriele König (Bonn) | Identification and characterisaton of medicinal plants and herbal substances |
Estrogens and progestins
| Peter Mayer Hans-Karl Heim | Evaluation of the pro-thrombotic potential of estrogen-progestin combinations |
Fluoroquinolone and HERG-channels
| Bernd-Joachim Zünkler | Effects of fluoroquinolone derivatives on HERG and ATP-sensitive K+ channels |
Smooth muscle cells and arteriosclerosis
| Peter Mayer Hans-Karl Heim | Pharmacological action on arteriosclerosis-relevant phenotypes of vascular smooth muscle cells |
| Hippocampal theta-oscillations in neurodegeneratvie diseases | Marco Weiergräber | Molecular and electrophysiological dissection of hippocampal theta-oscillations - etiopathogenetic and diagnostic relevance in neurodegenerative diseases |
Photogenotoxicity testing in vitro
| Peter Kasper Roland Frötschl | In vitro photogenotoxicity tests as an alternative to photocarcinogenicity studies with rodents (Joint project supported by the German Federal Ministry of Education and Research, BMBF project no. 0312916A) |
Insulin degrading enzyme
| Giersig (BfArM) Schmitt, München | Characterization of protein expression of the Zn++-dependent metalloproteinasis, the Insulin-Degrading Enzyme, in tumor tissue and serum of breast cancer patients and its correlation with disease progression and response to cancer therapy |
| Interactions elastomer / protein containing drugs | Cornelia Lipperheide Uwe Lipke Thomas Zapf | Potential interactions between protein containing parenteral solutions and elastomeric closures |
In Ovo Carcinogenicity Assay (IOCA)
| Karsten Spicher Harald Enzmann | Characterization of Neoplastic Cell Alterations in the In-Ovo-Carcinogenicity-Assay (IOCA) |
| Coronary Annexin V - PET/CT | Dirk von Mallek Josef Zündorf Christof Krummeich Stefan Guhlke (Bonn) | Gallium-68 and fluor-18 labeled Annexin V analoga for imaging of vulnerable plaques of coronar vessels for PET |
Drug-induced mitochondrial toxicity
| Doris Höschele | Influence of the antibacterial substances Chloramphenicol, Tetracyclin and Linezolid on mitochondrial protein synthesis in HepG2 cells |
| MRSA phagocytosis | Norbert Schnitzler Josef Zündorf | Defense mechanisms of polymorhonuclear leukocytes against Methicillin-resistant Staphylococcus aureus (MRSA) |
| p53 and mechanisms of genotoxicity | Roland Frötschl | Characterization of the activity of substances with different genotoxic modes of action on the p53 pathway and apoptosis in cell cultures derived from liver, blood, and neuronal cells |
Phagocytosis A Abstract (file size: 11 KB) | Norbert Schnitzler | Effect of Fluoroquinolones on phagocytosis of pathogenic microorganisms by human polymorphonuclear neutrophils |
Phagocytosis B
| Josef Zündorf | Effect of Perfluorocarbons on phagocytosis, oxidative burst and killing of pathogenic microorganisms by polymorphonuclear neutrophils |
Development/induction of resistance in hyphomycetes
| Regine Horré | Studies on the development/induction of resistance in "Emerging Fungal Pathogens". As model organisms strains of Scedosporium spp. and Pseudallescheria spp. will be examined. |
Signal transduction in granulocytes
| Thomas Grüger Norbert Schnitzler | "Outside-in" and "Inside-out signalling" during activation of human polymorphonuclear neutrophils |
Evaluation of irradiated plastic primary packaging material used for medicinal products
| Christof Krummeich | Ionising radiation is widely used today for sterilisation of plastic packaging material of medicinal products. The project investigates the influence of the ionising radiation on the quality of the packaging material and the quality of the medicinal product |
Toxicogenomics
| Peter Kasper Roland Frötschl | Application of gene expression profiling tools (DNA microarrays) for identifying (geno)toxic mechanisms of action |
Toxicity AIDS
| Doris Höschele | Investigating mitochondrial toxicity of HIV Nucleoside Reverse Transcriptase Inhibitors in ovo |