Valproic acid/valproate: Interaction with carbapenems
created: 2010.06.17
updated: 2010.06.17
The product information texts on all valproic acid or products containing valproates should include warnings about clinically relevant interactions with carbapenems (decreased valproate plasma concentration) to come up to the latest findings. The intended measures are due to an EU recommendation. A hearing in writing under the graduated plan procedure (Stufenplan), stage II, will follow.
risk information - full text (available in German only)