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Tamoxifen: Interaction with SSRIs (selective serotonin reuptake inhibitors)

A Canadian cohort study showed that the SSRI, paroxetin, may decrease the effect of tamoxifen in a hormone therapy of mamma carcinoma (BMJ 2010; 340:c693). Concomitant administration of tamoxifen and paroxetin was found to increase breast cancer mortality.

risk information - full text (available in German only)