Active substance: Ruxolitinib phosphate The company Incyte Biosciences Distribution B.V. informs about possible particles in Opzelura 15 mg/g cream, which may form during production from the active substance.

Active substance: Nitrous Oxide, Oxygen The company Linde Sverige AB informs about a quality defect of the medicinal product Livopan when used with a Fir Tree connector for direct connection with O₂/N₂O breathing systems.

Active substance: naltrexone, bupropion EMA’s human medicines committee (CHMP) has finalised its review of Mysimba (naltrexone / bupropion), regarding the potential long-term cardiovascular risk (affecting the heart and blood circulation).

Active substance: metamizole With the publication of the European Commission's decision, the risk assessment procedure on the medicinal products containing metamizole has been completed.

Active substance: Aztreonam, Avibactam The company Pfizer Europe MA EEIG informs about the risk of broken or cracked glass vials of  Emblaveo 1.5 g/0.5 g  powder for concentrate for solution for infusion.

Active substance: ribociclib The company Novartis Pharma GmbH informs about a change to storage condtions and shelf life of Kisqali 200 mg film tablets.

Active substance: fezolinetant The marketing authorisation holder of Veoza (fezolinetant) would like to inform about the risk of drug-induced liver injury.

Active substance: voxelotor The European Commission has decided to suspend the marketing authorization for the medicinal product Oxbryta (voxelotor) for sickle cell disease. This is a precautionary measure during the review of new data.

Active substance: metamizole The marketing authorisation holders of metamizole-containing medicinal products provide information on the early symptoms of agranulocytosis.

Active substance: Hydroxycobalamin The company SERB SA informs about a potential microbial contamination and a possible resulting risk of infection.

Active substance: Budesonide and Formoterole The company Sandoz GmbH informs about a possible failure of dose delivery in several batches of Airbufo Forspiro.