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Drug allergies, cutaneous adverse drug reactions and dedicated pharmacovigilance questions

Drug allergies depend on the individual characteristics of the patient and, unlike most other adverse drug reactions (ADRs), are therefore typically unpredictable. Although they account for a smaller proportion of all ADRs, some of these reactions, such as anaphylaxis or angioedema (swelling of the face), can be severe and potentially life-threatening.

Due to their visibility, cutaneous ADRs are more easily recognized than ADRs in other organs. The clinical spectrum ranges from mild rashes to life-threatening diseases that lead to blistering and detachment of large areas of the skin. In addition, cutaneous ADRs can also indicate ADRs affecting other organs.

Dedicated pharmacovigilance questions refer for example to the occurrence of ADRs in particularly sensitive patient groups such as children or the elderly.