Dear Doctor Letter
So-called "Dear Doctor Letters" ("Rote-Hand-Brief") are circulated in order to pass on safety relevant information on a medicinal product to physicians and pharmacists as quickly as possible. Both the envelopes of these letters as well as the information itself bear the symbol of a red hand. "Dear Doctor Letters" are sent out by the pharmaceutical entrepreneur in consultation with the federal higher authority ("Bundesoberbehörde") competent for the medicinal product (BfArM or Paul-Ehrlich-Institut). These "Dear Doctor Letters" can contain e.g. information regarding previously unknown severe adverse reactions or changes in the indications of the medicinal product. Such new findings are often the result of the BfArM's monitoring of medicinal products. After authorisation of a medicinal product, the BfArM collects experience with its use systematically and on an ongoing basis and analyses this information.